/r/AskScience Vaccines Megathread

http://www.nejm.org/doi/full/10.1056/NEJM199705293362203 Bishop et al., N Engl J Med 1997; 336:1557-1562 "Aluminum Neurotoxicity in Preterm Infants Receiving Intravenous-Feeding Solutions" reported that every 40mcg of intravenous aluminum per kg injected into preterm infants was associated with an average drop of 1 point on the mental development test at 18 months, (and also a loss of bone density at 15 years of age http://www.ncbi.nlm.nih.gov/pubmed/19858156).

The Hep B vaccine given at birth, 1 month, and 6 months contains 250 mcg and the Vax series 4000 mcg over the first six months. If we assume a microgram of aluminum does half as much damage injected in a 4 kg neonate as a 2kg one, and model 1 development point as 1 IQ point, vaccine aluminum is projected to cause a loss of 15 IQ points. And bone density.

If you look at the FDA webpage entitled "Study Reports Aluminum in Vaccines Poses Extremely Low Risk to Infants" http://www.fda.gov/BiologicsBloodVaccines/ScienceResearch/ucm284520.htm the study they are referring to is Mitkus et al. Mitkus et al is a mathematical model, they made NO observations or measurements at all. And the model is based on experiments feeding aluminum to weaned animals. It is not informed about the toxicity of injected aluminum in neo-nates in any way. Why would they prefer that to the direct measurement of the toxicity found in Bishop et al?

Moreover, every epidemiological paper I'm aware of that actually compares patients who got more aluminum in vaccines to those who got less, finds results showing less is better, and Bishop et al is further confirmed in an animal model. Administration of aluminum to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes C.A. Shaw, Y. Li , L. Tomljenovic, Journal of Inorganic Biochemistry, V 128, November 2013, Pages 237–244 http://www.sciencedirect.com/science/article/pii/S0162013413001773

So my question is, what empirical basis is there, and please provide citations, to conclude the aluminum in the vaccines is anything but damaging?

/r/askscience Thread