I do it like this:

Games where aiming is really important always get full mouse/ keyboard mode with gyro.

I use keyboard/mouse/gyro mode for FPS like Far Cry 4, CSGO, Half Life 2, Portal, Metro Last Light and Third Person Shooters like Max Payne 3, Spec Ops The Line, The Evil Within. For these games i always use complete keyboard and mouse mode with gyro.

Then there are games where movement/parcour/platforming/driving are more important than precise aiming.

3d action adventure/open world games such as Mad Max, Ryse, The Witcher 3, Bully Scholarship Edition, Grow Home, Assassins Creed, DMC etc. For those games i use full gamepad mode so i can have analog movement, gamepad button prompts and i dont really have to change the configuration around all that much.

All I really change for those games is set the right trackpad to mouse like joystick with a generous Edge Spin Radius and Edge Spin Speed so i can pan the camera around by simply holding the edge of the trackpad, then i put gamepad look sensitivity ingame to 100 %.

There are really only a few games in my library that fall kind of in between where neither approach is really perfect.

GTA V has a lot of shooting but i prefer to use gamepad mode (i just turn on assisted free aim mode so i get some aim assist) because i feel like driving, flying, minigames are a bigger part of the gameplay than shooting.

Fallout 4 really calls for mouse/keyboard mode and that is what i use but it took a lot of time to get the menu navigation with a mouse and keyboard config to not suck. Mixed mode would be really helpful in this game.

I heard its similar in Metal Gear Solid 5 but i dont have that game yet.

I dont really use mixed Mouse/ Gamepad mode at all because in the games i tried it there were always some annoying quirks with it and in some games it didnt work at all so i just choose beforehand if aiming is more important or analog movement is more important and then stick with either full M/KB or full gamepad.