Now more than ever is the right time to end it. It sounds like the issues you have with her are fundamental changes that are near impossible for any reasonable human to achieve. I’d love to think you two can talk out your problems and settle your differences, but from what you’ve described, that seems pretty un-plausible. But hey, maybe this is something you two can work out. Maybe you can have a talk with her about these things— it really comes down to your willingness to keep this relationship alive. But at the end of the day, if you’re really not happy, it will begin to show and it’s going to be hard for the both of you. I trust you’ll do the right thing, and don’t feel guilty about which choice you make. You’re doing it for the both of you.