What do you consider life's greatest lie?

Absolutely, life is not fair

Warren Buffett, one of the richest persons in the world, attributed his success to "winning the Ovarian Lottery":

In a clip found using CNBC's Warren Buffett Archive, Buffett explained the concept of the "ovarian lottery" at Berkshire Hathaway's Annual Shareholders Meeting in 1997 to mean that many of the advantages you get in life, such as your nationality or your health, are determined by chance.

Born in the right place, at the right time, and to the right family (including a healthy set of genes) is a key advantage

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