The uncertainty principle is basically saying that we have to shoot a photon etc into something to observe it. It just means there is a limit to how precise measurements can be and how many layers of reality we can peel back as we go further down in scale. Just because we can't have an undisturbed system of observing doesn't mean that we should expect that reality suddenly breaks at some point beyond what we can detect. It's wishful thinking to assume that the mechanism required to distinguish ourselves from predetermined collisions of particles lies conveniently beyond our reach in the quantum world.

It gets even more complicated when you try and answer what kind of mechanism would provide free will. Random is just having no predetermined sequence so it's not really a solution. If DNA somehow created organisms that are subject to random quantum fluctuations, those are just logical curve-balls in your neural wiring which would mean that what feels like aware choices are just various coin tosses that eventually gain a bias as you have more memory to draw upon.

A good place to take this debate is to computing. Despite our advances, we may never be able to create true non-deterministic computer agency. Given the source code and all forms of input, you can calculate the exact output even if that output includes adjusting/appending its own source code which to me sounds exactly how human awareness and agency work. Just look at how primitive our random number generators are. The best ones use external stimuli like radioactive decay to offset the generation.

It's a really depressing topic because once you start to understand it, it becomes very difficult to conceive something that can escape the action/reaction nature of reality. Random isn't any more hopeful because that's just coin flipping.