I’m a former Paramedic; we don’t have a natural layer of ‘protective oil’ that protects us from pathogens, the ‘upwelling effect’ of new skin cells forming underneath the dead layer is what makes pathogens less likely to permeate our skin. There are some that can however, like the one behind necrotizing fasciitis a disease where the best case scenario is being maimed. Hand sanitizer does dehydrate skin and remove oils, but all that oil does is keep our skin flexible and stretchy, nothing else. Yes, that does also come under good hand hygiene, but during this pandemic you also need to increase the frequency of your hand washing to protect yourself and those around you. Also, a tissue is permeable so medically speaking, offers zero protection from a virus without hand-washing also.