The only thing I can think of is consistently making speculative plays with a low chance to draw into the right cards, but then it working out perfectly for you. Rather than taking chip damage for a guaranteed kill next turn, the correct cards are drawn for lethal out of pure luck against the odds which saves hp.

It’d be so ridiculously hard to find full runs to work from like this though, even with using ai. It’s probably doable against Jaw Worm with the starter deck and as few variables as possible. 18hp jaw worm dealing 12 damage - 2xDefend for 10 and Strike for 6 damage, or 3xDefend for 15 and hope you draw all 3 Strikes out of 6 cards next turn? This misplay could potentially save you 2hp, or cost much more if you don’t get lucky, but could end up being the difference between success and death later in the act