This is going to be hard for me to type, because I'm an avid fan of socialised medicine and believe the current system in the U.S. is deeply flawed.
I watched the whole video with a bias that this guy was going to be a scumbag, but as a capitalist and I would say a pragmatist, I found myself agreeing with him.
The reason why many capitalist countries are innovative is because there is a real monetary gain/reward to be had for working hard and innovating. By making AIDs medication profitable, more money will be invested into the research of it in search of further profits, thereby having a real effect on AIDs treatment, and finally the introduction of better medicines. For better or worse, capitalism works because most people will only be interested in themselves, and by making medication lucrative, money and research will be spent into it chasing more profit.
If what he's saying is true, $5 million of revenue for a producer of a life-changing drug really is ridiculously low, and frankly inappropriate. Everything has a value attached to it, and I do agree that a course of this medication is worth far more than $1,000. Frankly if his company actually is doing groundbreaking work, they should be rewarded appropriately, so they can continue doing good work.
I agree with his principles and reasoning, and I think it is small minded to ignore the economic realities of such things.
HOWEVER.
I feel the 5,500% increase is exorbitant, but as he mentioned similar medicines still cost far more than this which is evidence of a wider problem. While I believe every business that helps humanity deserves healthy profits to continue, the pharmaceutical industry in the U.S. as a whole is currently sick.
In my opinion, the price increase from $1,000 for treatment is justified, however it should have only increased to something "reasonable", such as say $20,000 (pulling this out of my ass). This would then increase the company's revenue to $100 million. The cost of the medicine should then be heavily subsidised by the government, by reducing spend on "defense" and increasing on health, with the end result of the medicine being accessible by citizens at either no cost or little cost.