Back to your original comment:
but i think a lot of grant money and effort is spent every year on irreproducible science and on low impact pre-clinical research that goes nowhere
Your small study of 30 rats needs money to be bigger. You need extra money to staff all the extra researchers for collaboration. You don't want money to go to these studies because they aren't good enough, but how is cutting funds and denying grants to these labs going to fix anything? What are you even trying to argue?
As for the journals, there will always be journals with higher impact factors than others. That is just a fact; get over it. Not every article is going to be in Nature. Not every article SHOULD be in Nature - your much more specific articles go in the specific journals. "Low-impact" doesn't necessarily mean "poor quality;" often it's a subfield or a sub-subfield of research that doesn't belong in Nature because it's not applicable to a broad range of research but IS very important for a smaller range. Academic institutions subscribe to most of the journals relevant to their work, and even if they don't subscribe to the one you need, they can get a copy of the article you want from another institution through their interlibrary loan services. Anyone with an internet connection can get on Pubmed and find all of the research relevant to their field, even if its in a low-impact journal, and check out the abstract and research group, and request a copy if it's not already available.
who do you think is actually reading the journals with the tiny ass impact factors? not many people.
...except everyone in that field. I don't read the Journal of Wound Ostomy & Continence Nursing because it's not relevant to my career or research, but I'm sure all of the WOC nurses read the shit out of it, and researchers in related fields read it too.
I have no idea what you're trying to argue and I don't think you do either. Not every journal is high-impact, not every person is a celebrity, not every athlete is a pro, get over it. If every journal is high-impact, then none are. And you're overestimating the importance of high-impact journals: if an article is published, you can find it easily if you put in an ounce of effort.