How do you know what dose you need?

That's not even close to what that placebo study showed. The only effect that failed placebo control was the "high", the one effect that only happens if the dose is too high. If anything, that study is more evidence that microdosing for depression isn't a placebo at all.

From the article you posted:

Those that actually microdosed the psychedelics did report increased markers of wellbeing, including higher rates of life satisfaction and mindfulness and lower rates of paranoia. But the participants were also asked to guess whether they had taken a placebo or not. And when these data were included, the researchers found a significant overlap in the reports from participants who thought they had taken the drugs, even when they hadn’t.

/r/microdosing Thread Parent