Its the way it trends. I don't ascribe anything to being a misanthrope in particular, only that someone might trend that way as a natural state of their being, with a host of causes.

It sounds more like the people you refer to are generally negative about a number of things and maybe not just people. Misanthropy just falls in there to the mix of negativity.

For instance, I have noted that there is a lot of reflection on the situation of humanity as it pertains, personally, to the individual as a sort of grudge or sense they have been wronged. This seems anathema to me because it necessitates that people concern me, that I should somehow want or share their attention or whatever drives them. Its a lack of my concern rather than a gripe towards somehow being "wronged." There are further complications but I won't get into them here.

When the mass of humanity trends towards the entirely of being wrong minded, and in this era willfully so, then that is what the alienating factor is.