As a high functioning autist (a subform called asperger) I can tell you that it's hard. A few core traits of this subform are reduced social prowess, reduced sympathy and a talent for math and logic.
Basically many social interactions don't come naturally and I have a harder time reading someone's emotions than a "normal" person would, which makes it harder to find friends, meet new people and keep social contacts going. This social awkwardness has also caused me to be a target of bullying until very late in high school.

I'm currently going through a depression because of my social life, or lack thereof. On an average week I spend 6/7 evenings at home and one at rehearsal with the orchestra I'm a member of. I have 2 friends who I regularly keep contact with and haven't had a girlfriend for about 1,5 year, during that time I also haven't even kissed a girl. Where "I don't have a life" is sometimes a funny joke, it's literally true for me. I'm actually pretty happy when I get a single text a day :/.
I've never wanted to be the most popular guy around, but this amount of social interaction is pretty dissatisfying tooz

There are positive things to it, due to logic coming to me very easily I have an easy time programming (I'm an IT student) and playing strategy based games (like chess or LoL), I'm also pretty amazing at solving Rubix cubes :p.
The next part may sound morbid but I also have an easier time dealing with loss, I get over breakups rather easily and although I miss the person, I don't cry at funerals.

I could keep going on but this post is already getting pretty lengthy and I think I've given enough examples of why it's hard even as a high functioning autist :p