could use something like CodeVirtualizer and deploying a new update to the game every 5-10 days will totally ruin hag makers and eventually just make them quit. each time an update comes out, they have to reverse engineer the game again and refind the structs and what not that they manipulate. so if you deploy new updates that frequently they will eventually just say the game is too much of a hassle and then quit trying.

then there is always the choice of making drivers run from ring 0 and protect the game from there, from any sort of memory manipulations (such as some antiviruses do), and/or you could even make a driver that monitors the SSDT and then catches when WriteProcessMemory or ReadProcessMemory is executed and you can squash those calls if they're pointed at the game. Obviously this is getting a bit more complex. but if you protected your game from ring 0 and caught those function calls, hackers would most likely come out with a driver with their own code for WriteProcessMemory and ReadProcessMemory (difficult, but definitely possible for experienced hackers), then you would need to do things like monitor certain Control Registers with other key things going on in the system to see if there is any memory manipulation going on (the key of that would be finding the area in memory your game is running and making sure nothing even attempts to get to that area, but then you have to make sure you don't interfere with the actual operating system, and of course this will cause issues with anti-viruses).

so in all honesty a good software protection and a frequent updates will definitely be the best way to go about this.

mfw ppl are fucking using modified shit tier hacks from 2013