We all agree that 300 lives has more value than the life of one and that’s why asking to vaccinate mathematically right now makes no sense.
I will let you do the research yourself but as of today the ratio of a severe side effects for (say) smallpox is 14-52 in 1 million vaccines. The last outbreak of smallpox in US was in 1949. So mathematically speaking as of today, vaccinating for smallpox is insanity. I understand the reasons for the lack of outbreak is due to the effectiveness of vaccine, and one can re-evaluate the vaccination decision once that ration changes. As of today though you are placing a higher value of a hypothetical non existent risk over the lives of those 15-52/1Mil.